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Neurosurgical Laboratory
Laboratory of Neural Control of Cardiovascular Function
This laboratory is involved in identification of neural structures controlling cardiovascular function, elucidation of interconnections between them and characterization of putative neurotransmitters mediating their functions. The laboratory is directed by Dr. Hreday N. Sapru, Professor, and includes significant contributions from Dr. Vineet C. Chitravanshi, Assistant Professor, and 4-5 research associates and post-doctoral fellows from time to time. Some of the observations relevant to this field of research were reported first from this laboratory. These include: identification of the rostral ventrolateral medullary pressor area (RVLM) and caudal ventrolateral medullary depressor area (CVLM) in the rat, demonstration that the CVLM is a relay nucleus between the nucleus tractus solitarius (NTS) and RVLM in mediating the baroreflex responses, identification of the role of gamma-aminobutyric acid (GABA) receptors in the RVLM during baro- and cardiopulmonary reflexes, identification of the chemoreceptor projection site (CPS) in the NTS of the rat, elucidation of the role of glutamate receptors in the projection from the RVLM to the intermediolateral cell column (IML), identification of the role glutamate receptors in the CPS, medial NTS, and phrenic motor nucleus in carotid chemo- and cardiopulmonary reflexes, demonstration of enkephalin-induced activation of cardiopulmonary vagal C afferents, identification of the role of opioid and other neuropeptides in the medullo-spinal cardiovascular regulatory areas, identification of a glutamatergic projection from the hypothalamic paraventricular nucleus (PVN) to the NTS and identification of pathways mediating cardiovascular actions of the hypothalamic arcuate nucleus. Current research focus includes studies on the alteration of central control mechanisms in pathophysiological states. Research reports from this laboratory have been published in 111 peer-reviewed papers in highly regarded journals, 14 book chapters and 5 reviews. The laboratory has been funded by National Institutes of Health for last 32 years. Residents seeking scientific training are encouraged to pursue a fellowship in this laboratory.
Researcher
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Hideki Arakawa, MD
Post-doctoral Fellow
Biography:
Dr. Hideki Arakawa is currently working as a post-doctoral fellow in the Department of Neurological surgery. He received his MD degree from University of Occupational and Environmental Health, Japan in 1998. He completed his residency and clinical training in occupational and environmental health at different universities in Japan in 2009 and joined this department as a post-doctoral trainee.
Peer-reviewed publications
  1. Hideki Arakawa, Jian-Yong Qian, Dolgor Baatar, Ken Karasawa, Yujiro Asada, Yasuyuki Sasaguri, Elizabeth R. Miller, Joseph L. Witztum, Hikaru Ueno. Local Expression of Platelet-Activating Factor-Acetylhydrolase Reduces Accumulation of Oxidized Lipoproteins and Inhibits Inflammation, Shear Stress-Induced Thrombosis, and Neointima Formation in Balloon-Injured Carotid Arteries in Nonhyperlipidemic Rabbits. Circulation. 111: 3302-3309, 2005.
  2. Arakawa H, Chitravanshi VC, Sapru HN. Hypothalamic arcuate nucleus: a new site of cardiovascular action of angiotensin-(1-12) and angiotensin II. Am. J. Physiol- Heart and Circ. Physiol. 300: H951–H960, 2011.