The Neurosurgery Traumatic Brain Injury (TBI) laboratory was established in 2008 with the goal of advancing our understanding of neuronal regeneration following TBI and developing new methods to improve that regeneration.
The Traumatic Brain Injury Laboratory, under the directorship of Dr. Chirag D. Gandhi, has a breath of on-going basic science and translational research dedicated to the goal of improving outcomes for Traumatic Brain Injuries. The Laboratory is currently supported by a multi-year grant from the New Jersey TBI Commission. This on-going IACUC Approved study is attempting to better characterize the behavior of neural cells after traumatic brain injury through transplantation of labeled stem-cells. Preliminary results will be presented at the upcoming Neurotrauma National Symposium. The laboratory in conjunction with the UMDNJ Department of Neuroscience and the New Jersey Institute of Technology, supports the thesis work of various Doctoral Candidates. Previous studies of the TBI Laboratory include:
- Transcranial magnetic stimulation in patients with traumatic brain injury (TBI).
- Use of MR-Spectroscopy to predict the emergence from coma or the vegetative state following TBI.
- The use of adjunct osmotic diuretics in the management of elevated intracranial pressure.
- Investigations of decompressive hemicraniectomy in the management of severe TBI.
The current study entitled “CNS Regeneration after TBI from Transplanted Neural Precursors” is a multi-investigator project funded by the New Jersey Commission on Brain Injury Research. In this study, we are characterizing the efficacy of injecting neural precursors (immature brain cells) around a region of brain injury. These neural precursors are obtained from either the subventricular zone or ventricular zone that are two areas within the mammal brain that contain large numbers of immature cells that have the potential to develop into a variety of brain cells and theoretically, improve central nervous system regeneration after injury. Preliminary data from this project was recently presented at the 2010 National Neurotrauma Symposium.
The next project that is being developed is in conjunction with the New Jersey Institute of Technology’s Biomedical Engineering faculty. In this study the goal will be to introduce the neural precursors along with a bioengineered scaffolding and additional supplementation into the injured brain. Our hypothesis is that the scaffolding and supplements will greatly improve implant survival, differentiation, and eventually, regeneration.
Mevan Siriwardane, MS
Frances Calderon, PhD